Jellyfish in ecosystems, online databases, and ecosystem models D. Patterns of jellyfish abundance in the North Atlantic M.J. PaulyĮxtension of methods for jellyfish and ctenophore trophic ecology to large-scale research J.E. LARGE SCALE APPROACHES The growth of jellyfishes M.L.D. Purcell Obituary: Francesc Page`s (1962–2007) J.-M. No part of this material protected by this copyright notice may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without written permission from the copyright owner. Printed on acid-free paper All Rights reserved 2008 Springer Science+Business Media B.V. 616 (2009).Ĭover illustration: An aggregation of the giant jellyfish, Nemopilema nomurai, in a set net in Kyoto Prefecture, Japan. AA Dordrecht, The NetherlandsĬite this publication as Hydrobiologia vol. Catalogue record for this book is available from the Library of Congress. Library of Congress Cataloging-in-Publication DataĪ C.I.P. Reprinted from Hydrobiologia, Volume 616 (2009) Jellyfish Blooms: Causes, Consequences, and Recent Advances Proceedings of the Second International Jellyfish Blooms Symposium, held at the Gold Coast, Queensland, Australia, 24–27 June, 2007 EditorsĪustralian Rivers Institute and Griffith School of Environment, Griffith University, Australia 2 Western Washington University, Shannon Point Marine Center, Washington, USA 74, 1104 (1952).Jellyfish Blooms: Causes, Consequences, and Recent Advances
in Organic Sulfur Compounds (ed Khurasch, N.) 326–338 (Pergamon, New York, 1961). in Biochemical Calculations 2nd edn, 256–257 (Wiley, New York, 1976).Īssony, S. in Neurotransmitter Receptor Binding (eds Yamamura, H. Skolnick, P., Syapin, P., Paugh, B., Moncada, V.
We now report the synthesis of a novel benzodiazepine, irazepine, which acts as a noncompetitive, irreversible inhibitor of 3H-diazepam binding to synaptosomal membranes. The development of noncompetitive, irreversible ligands has been invaluable in the characterisation, isolation and purification of both peripheral and central neurotransmitter receptors 15, and may also prove useful for studying the benzodiazepine receptor. Competitive inhibition of 3H-diazepam binding has also been observed with the triazolopyridazines, which possess both anticonvulsant and anxiolytic activity 9, and with the purines inosine and hypoxanthine 10,11, which may be endogenous ligands to the benzodiazepine receptor 10–14. Benzodiazepines such as clonazepam, oxazepam and flurazepam are rapidly reversible, competitive inhibitors of 3H-diazepam binding to synaptosomal membranes 7,8.
The correlations obtained between the in vitro affinities of a series of benzodiazepines for these binding sites and their clinical potencies as muscle relaxants 2, anxiolytics 6 and anticonvulsants 6 strongly suggest that these sites are pharmacological receptors mediating the therapeutic actions of the benzodiazepines. THE identification and characterisation of stereospecific, high-affinity binding sites for benzodiazepines in the mammalian CNS has been described both in vivo 1–3 and in vitro 4–6.